ISSN 2149-7893 | E-ISSN 2536-507X
Original Article
Importance of Thiol/Disulphide Homeostasis and Neutrophil-Lymphocyte Ratio in Diagnosis of Urinary Tract Infections in the Emergency Department
1 Department of Emergency Medicine, Ankara Yıldırım Beyazıt University Medical School, Ankara, Turkey  
2 Department of Emergency Medicine, Ankara Atatürk Training and Research Hospital, Ankara, Turkey  
3 Department of Biochemistry, Ankara Yıldırım Beyazıt University Medical School, Ankara, Turkey  
Cyprus J Med Sci ; : -
DOI: 10.5152/cjms.2019.704
Key Words: Thiol/Disulphide homeostasis, Urinary Tract Infection, Neutrophil Lymphocyte Ratio
Abstract

BACKGROUND/AIM: The aim of this study is to investigate the diagnostic utility of thiol/disulphide homeostasis parameters which are oxidative stress markers together with Neutrophil-Lymphocyte Ratio (NLR) in diagnosis of urinary tract infections in emergency department patients.

 

MATERIAL and METHODS: The study was conducted prospectively with 63 patients who were admitted to the emergency department between 01.05.2017 and 31.03.2018 and 59 healthy subjects who were determined as control group. A new method developed by Erel and Neşelioğlu was used to measure Thiol/disulphide homeostasis parameters (Thiol, disulphide, disulphide/native thiol, disulphide/total thiol, native thiol/total thiol) and NLR were studied in the patient and control group. In addition the relationship between these parameters and body temperature and urinary cultures in patients with urinary tract infection were investigated too.

 

RESULTS: NLR, disulphide/native thiol and disulphide/total thiol mean values were found significantly higher (p<0.001, 0.013 and 0.009 respectively) in patients with urinary tract infection compared to the control group. Disulphide, disulphide /native thiol and disulphide /total thiol mean values were found significantly higher (p <0.001, <0.001 and <0.001 respectively) in the group with high body temperature compared to the group without high temperature. Native thiol and total thiol values were found significantly lower (p=0.048 and =0.020 respectively) in the group with positive urine culture compared to the group with negative urine culture.

 

CONCLUSION: Thiol/disulphide homeostasis parameters together with NLR values are diagnostically useful in patients with urinary tract infections.

Key Words
Authors
All
Author's Corner
Survey
AVES | Copyright © 2018 Cyprus Turkish Medical Association Latest Update: 03.01.2019