Original Article

Can Preoperative Complete Blood Count Parameters Be Used as Predictive Markers for Lymph Node Metastasis in Endometrial Carcinomas?


  • Emre Erdem Taş
  • Eyyüp Özgen
  • Ayşe Filiz Yavuz

Received Date: 14.09.2018 Accepted Date: 29.10.2018 Cyprus J Med Sci 2018;3(3):168-172


To investigate the clinical utility of complete blood count (CBC) parameters in the preoperative diagnosis of lymph node involvement (LNI) in endometrial carcinomas (ECs).


We conducted a retrospective study of 159 patients with ECs who underwent complete staging surgery at a tertiary center between 2007 and 2017. After demographic characteristics and preoperative CBC parameters were retrieved from the patients’ medical records, the patients were grouped according to lymph node status (positive and negative) and compared. Variables with p<0.05 were included in the logistic regression analysis, and receiver operating characteristic curve analysis was used to determine the cut-off values for predicting LNI.


The mean age of the patients was 59.1 years, and 14 (8.8%) patients had LNI. The mean white blood cell, neutrophil, and platelet counts; plateletcrit level; and neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios were significantly higher in patients with LNI. Logistic regression analysis identified an independent association between increased neutrophil count and LNI (odds ratio 5.12; p<0.05). The optimal cut-off value was 4.85 (×103/μL) (sensitivity, 77.4% and specificity, 74.2%). A cut-off of 6.25 (×103/μL) was used to identify LNI with 100% specificity.


An increased neutrophil count can be considered a useful additional tool for the preoperative diagnosis of LNI.

Keywords: Blood cell count, endometrial neoplasms, lymphatic metastasis, lymph node excision, neutrophils