E-ISSN: 2536-507X ISSN: 2149-7893
Conservative Treatment for Locally Advanced Carcinoma of the Larynx Using Alpha-Crystalline B as a Prognostic Molecular Marker
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Original Article
VOLUME: 5 ISSUE: 4
P: 317-322
December 2020

Conservative Treatment for Locally Advanced Carcinoma of the Larynx Using Alpha-Crystalline B as a Prognostic Molecular Marker

Cyprus J Med Sci 2020;5(4):317-322
DOI: 10.5152/cjms.2020.1937
Rajab Alzahrani 1
AbdulRahman N Alghamdi 2
Ashjan Shami 3
Wael H Elsawy 4
Amal F Gharib 3,5
Hanan S. Amin 6
Majed AlMourgi 7
1. Department of Surgery, Otolaryngology Division, Medical College, Al Baha University, Al Baha, Saudi Arabia
2. Department of Family Medicine, Medical College, Taif University, Taif, Saudi Arabia
3. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia
4. Department of Clinical Oncology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
5. Department of Medical Biochemistry, Faculty of Medicine, Zagazig University, Zagazig, Egypt
6. Department of Clinical Chemistry, Theodor Bilharz Research Institute, Cairo, Egypt
7. Department of Surgery, Medical College, Taif University, Taif, Saudi Arabia
No information available.
No information available
Received Date: 05.04.2020
Accepted Date: 29.08.2020
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ABSTRACT

BACKGROUND/AIMS

This study was performed to understand the prognostic role of alpha-crystalline B (αBC) in locally advanced laryngeal cancer.

MATERIAL and METHODS

Forty-five patients were enrolled; they were treated with induction chemotherapy followed by definitive radiotherapy. Alpha-crystalline B (αBC) was evaluated using quantitative real time-polymerase chain reaction.

RESULTS

Complete response to induction chemotherapy was observed in 16 patients, and partial response was achieved in 27 patients. After radiation therapy, 32 patients showed complete response. The αBC level was significantly higher in the tumor tissues than in the normal adjacent tissues. This level was significantly correlated with the patient’s age, clinical stage, and treatment response. High αBC levels were significantly associated with short overall and disease-free survival.

CONCLUSION

Induction chemotherapy can efficiently preserve the larynx in a high proportion of patients. αBC can be used as a molecular marker for predicting the treatment response and survival in patients undergoing induction chemotherapy.