ABSTRACT

The mean platelet volume (MPV) is used nowadays to predict the cancer prognosis. As the incidence of muscle-invasive bladder cancer (MIBC) is rising, we aimed to determine the disease-specific survival (DSS) and overall survival (OAS) rates in MIBC using MPV in patients who underwent radical cystectomy.

This is a retrospective analysis of data from an ongoing bladder cancer project. A total of 168 patients with bladder cancer who underwent cystectomy were enrolled between February 2006 and 2016. A potential prognostic value of MPV was evaluated using the receiver operating characteristic (ROC) curve analysis. We examined the impact of MPV on patients’ DSS and OAS. ROC curves were drawn. A p-value <0.05 was considered to be statistically significant.

The mean age was 62.10±9.26 years. There were 156 (92.9%) men and 12 (7.1%) women. The optimal MPV cutoff value for DSS was 8.37fL. The group with a lower MPV showed worse progression with regard to DSS and OAS (p<0.001). Age (p=0.024), MPV (p=0.001) were independent prognostic factors for predicting DSS. Additionally age (p=0.003), and MPV (p<0.001) were determined as independent prognostic factors for predicting OAS.

A decreased MPV can be an independent prognostic factor in patients with MIBC. If the MPV is lower than 8.37fL, DSS and OAS may worsen.