Cyprus Journal of Medical Sciences
Original Article
Effects of Alprazolam and Clonazepam on Blood Sugar in Patients with Panic Disorder

Effects of Alprazolam and Clonazepam on Blood Sugar in Patients with Panic Disorder

1.

Department of Pharmacology, Babol University of Medical Sciences, Babol, Iran

2.

Department Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

3.

Department of General Practice, Faculty of Medicine, Babol University of Medical Sciences

4.

Department of Internal Medicine, Yahyanejad Hospital, Babol University of Medical Sciences, Babol, Iran

5.

Department of Psychiatry, Babol University of Medical Sciences, Babol, Iran

6.

Department of Internal Medicine, Tehran University of Medical Sciences, Tehran, Iran

Cyprus J Med Sci 2019; 4: 195-200
DOI: 10.5152/cjms.2019.716
Read: 111 Downloads: 45 Published: 23 December 2019

BACKGROUND/AIMS

Panic disorder is one of the most common anxiety disorders with a good pharmacotherapeutic response. Benzodiazepines are one type of such efficient medications. This study aimed to evaluate the impact of alprazolam and clonazepam on blood sugar of adults with panic disorder.

 

MATERIAL and METHODS

This randomized controlled trial recruited 45 patients suffering from panic disorder. After filling out the initial questionnaire and measuring patients’ height and weight, fasting and 2-hour postprandial blood sugar and glycosylated hemoglobin (HgA1c) were measured. Then, the patients were randomly allocated into three groups of sertraline, sertraline+alprazolam, and sertraline+clonazepam. After 3 months of treatment, the lab tests were repeated, and the data were analyzed using the statistical analysis software SPSS 18.

 

RESULTS

A total of 32 women and 13 men with a mean age of 28.98±6.8 years were recruited. Demographic characteristics and history of physical and psychological diseases did not show any significant differences among the three groups (p>0.05). At the end of the 3rd treatment month, the mean of 2-hour postprandial blood sugar (p=0.032) and HgA1c (p=0.0007) were decreased in the sertraline group, while the mean level of fasting blood sugar (p=0.006) and 2-hour postprandial blood sugar (p=0.015), and HgA1c (p=0.015) revealed a significant increase in the sertraline+alprazolam group.

 

CONCLUSION

This study showed that the treatment with alprazolam can cause an increase in the blood glucose in non-diabetic patients suffering from panic disorder.

 

Cite this article as: Moghadamnia AA, Moudi S, Tamaskani N, Saleki M, Hamidia A, Mouodi M, et al. Effects of Alprazolam and Clonazepam on Blood Sugar in Patients with Panic Disorder. Cyprus J Med Sci 2019; 4(3): 195-200.

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ISSN2149-7893 EISSN 2536-507X
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