Cyprus Journal of Medical Sciences
Original Article

HPV: Obvious but Not Necessary Cause of Cervical Cancer

1.

Department of Medical Pathology, Near East University School of Medicine, Nicosia, Cyprus

2.

Department of Medical Biology, Near East University School of Medicine, Nicosia, Cyprus

3.

Department of Medical Genetics, Near East University School of Medicine, Nicosia, Cyprus

4.

Near East University, DESAM Institute, Nicosia, Cyprus

Cyprus J Med Sci 2020; 5: 107-112
DOI: 10.5152/cjms.2020.963
Read: 213 Downloads: 190 Published: 29 June 2020

BACKGROUND/AIMS: Cervical cancer is one of the most common cancers worldwide. Human papilomavirus (HPV) has been proposed to be one of the main players in the development of cervical cancer. The aim of this study was to investigate the association of HPV DNA and cervical cytology.

MATERIAL and METHODS: A total of 201 women undergoing routine gynaecological check up in Hospital were recruited. HPV genotyping and cervical Pap test were analysed.

RESULTS: Overall, 42% (85/201) of women analysed were tested positive for at least one of the HPV types tested. HPV DNA prevalence was the highest in women younger than 30 years old (59%, 50/85). Eighty four percent (71/85) of the HPV positive women had low to high grade cytological anomalies.

CONCLUSION: The presence of HPV DNA was strongly associated with the cytological anomalies, especially with specific HPV types. This study showed that detection of multiple HPV types is rather important in understanding the possible crosstalk among HPVs during the initiation and progression of cervical lesions. In conclusion, HPV still remains to be the most prevalent marker for cervical cancer and thus regular check up should be evaluated as a preventative policy for cervical cancer.

Cite this article as: Mocan G, Tulay P, Özkayalar H, Serakıncı N. HPV: Obvious but Not Necessary Cause of Cervical Cancer. Cyprus J Med Sci 2020; 5(2): 107-12.

Files
ISSN2149-7893 EISSN 2536-507X