Cyprus Journal of Medical Sciences
Case Report

Imaging Features of Non-Enhancing Diffuse Midline Gliomas (DMG) with Histone H3 K27M Mutation: Spectroscopy and Perfusion Imaging Findings


Department of Radiology, Near East University Faculty of Medicine, Northern Cyprus, Turkey


Department of Radiology, Dr. Suat Gunsel University of Kyrenia Hospital, Northern Cyprus, Turkey

Cyprus J Med Sci 2021; 6: 270-272
DOI: 10.5152/cjms.2020.1360
Read: 124 Downloads: 56 Published: 03 April 2020

Diffuse midline gliomas (DMG) with histone H3 K27 mutation is a brand-new tumor according to the 2016 World Health Organization Classification of Tumors of the Central Nervous System. In this case report, we characterize the magnetic resonance imaging aspects with the literature review. Instead of biopsy, Magnetic Resonance Imaging (MRI) techniques are used to diagnose the tumor and determine the treatment choice despite the correlation with the prognosis. We present the case of high-grade astrocytic tumors with H3 K27 mutation in a 19-year old woman. Magnetic Resonance Imaging revealed a diffuse midline glioma. There was no paralysis of extremities or cerebellar deficit detected in physical examination. MRI showed a tumor in the pons, which is a hypo intense on T1 - weighted imaging and a hyper intense on T2- weighted imaging. A non-enhancing lesion was discovered during a Gd-MRI examination. In perfusion imaging, there was no distinct perfusion rising in the tumor. NAA: Cr ratio was 0.57 and Cho: Cr ratio was 0.78. In conclusion, perfusion and spectroscopy findings are helpful for non- enhancing DMG diagnosis.

Cite this article as: Tuncyurek O, Dirik MA, Bulakbası N. Imaging Features of Nonenhancing Diffuse Midline Gliomas (DMG) with Histone H3 K27M Mutation: Spectroscopy and Perfusion Imaging Findings. Cyprus J Med Sci. 2021; 6(3): 265-267.

ISSN 2149-7893 EISSN 2536-507X