Cyprus Journal of Medical Sciences
Original Article

Outcomes of Chronic Hepatitis B Virus Infection in Children: A 20-Year Follow-up

1.

Department of Pediatric gastroenterology, Şişli Hamidiye Etfal Training and Research Hospital, İstabul, Turkey

2.

Department of Pediatrics, Şişli Hamidiye Etfal Training and Research Hospital, İstabul, Turkey

3.

Department of Pediatrics, İstinye State Hospital, İstanbul, Turkey

Cyprus J Med Sci 2019; 4: 77-83
DOI: 10.5152/cjms.2019.817
Read: 148 Downloads: 152 Published: 29 August 2019

BACKGROUND/AIMS

The aim of the present study was to evaluate seroconversion rates in children with chronic hepatitis B (CHB) infection and determine the factors influencing the natural course of liver diseases.

 

MATERIAL and METHODS

A total of 458 hepatitis B surface antigen (HBsAg)-positive patients aged 0.75–17 years were tested for hepatitis markers, liver function tests, and hepatitis B virus (HBV) DNA levels at baseline and periodically at every 3 months following recruitment. Patients with CHB (n=321) were divided into two groups: treated and untreated patients. The seroconversion rates between the two groups were compared, and their relationship with age, sex, vaccination status, coinfections, aminotransferases, HBV DNA levels, and cirrhosis was determined.

 

RESULTS

Hepatitis B e antigen (HBeAg) seroconversion rates were 30 in 97 patients 30/97 (30.9%) in untreated patients and 67/147 (45.5%) in treated patients (p=0.023). HBsAg seroconversion rates were 10/174 (5.7%) in untreated patients and 16/147 (10.8%) in treated patients (p=0.10). No significant difference was observed in HBeAg and HBsAg seroconversion times between the two groups (p>0.05).

 

CONCLUSION

In our study, although the HBeAg seroconversion rate was significantly higher in treated patients than in untreated patients, the HBsAg seroconversion rate was not different between the groups.

 

Cite this article as: Urgancı N, Kalyoncu D. Outcomes of Chronic Hepatitis B Virus Infection in Children: A 20-Year Follow-up. Cyprus J Med Sci 2019; 4(2): 77-83.

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ISSN2149-7893 EISSN 2536-507X
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