Cyprus Journal of Medical Sciences
Original Article

The Prevalence and Patient Characteristics of Primary Antibody Deficiencies in a Tertiary Care Setting in North Cyprus

1.

Department of Immunology, University of Kyrenia School of Medicine, Kyrenia, Cyprus

2.

Department of Pediatrics, Near East University School of Medicine, Nicosia, Cyprus

Cyprus J Med Sci 2020; 5: 1-6
DOI: 10.5152/cjms.2020.866
Read: 191 Downloads: 118 Published: 07 April 2020

BACKGROUND/AIMS

Primary antibody deficiencies (PADs) are the most common group of primary immunodeficiency disorders that present with a wide range of clinical features. We conducted this study to evaluate the frequency and characteristics of patients with PADs.

MATERIAL and METHODS

The medical records of 160 children (M:F 99:61, mean age 42.39±28.44 months) were retrospectively reviewed from the Near East University Hospital database. Children who had PADs were then compared according to their demographic, clinical, and laboratory findings.

RESULTS

A total of 97 children were diagnosed with PADs (49 THGI, 31 IgGD, 1 SIgAD, 8 CVID, 6 IgMD, and 2 PHGI)*. Patients with THGI had the youngest age at the time of diagnosis (27±16.40 months), and those with CVID had the oldest age at the time of diagnosis (81.62±49.9 months old) compared with children in other PAD groups. In the HGG group, 63.9% of children presented with both recurrent wheezing/cough and infections, 22.7% had only recurrent infection, 13.4% of them had only recurrent wheezing/cough, and 71.7% of the children were atopic. At the end of the 2-year follow-up period, 8 patients (5 THGI and 3 IgGSD) out of 70 with HGG recovered.

CONCLUSION

PADs generally present with recurrent infections and/or recurrent bronchoconstriction unresponsive to standard asthma treatment. Evaluation of the immune system is important to increase the quality of life of these patients and also decrease the healthcare costs.

Cite this article as: Yürüker O, Şanlıdağ B, Bahçeciler NN. The Prevalence and Patient Characteristics of Primary Antibody Deficiencies in a Tertiary Care Setting in North Cyprus. Cyprus J Med Sci 2020; 5(1): 1-6.

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ISSN2149-7893 EISSN 2536-507X