ISSN 2149-7893 | E-ISSN 2536-507X
Original Article
Is There Any Correlation Between Preoperative Platelet Indices and Surgical Prognostic Factors in Patients with Cervical Cancer?
1 Department of Obstetrics and Gynecology, Ankara Yıldırım Beyazıt University School of Medicine, Ankara, Turkey  
2 Department of Obstetrics and Gynecology, Ankara Atatürk Training and Research Hospital, Ankara, Turkey  
Cyprus J Med Sci 2019; 4: 38-42
DOI: 10.5152/cjms.2019.676
Key Words: Mean platelet volume, platelet count, prognosis, uterine cervical neoplasms





To evaluate the variations in platelet indices (PIs), including platelet count, mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT), in cervical cancer (CC) and to evaluate the relationship between these PIs and pathological features of tumor (i.e., tumor stage and size, depth of stromal invasion, lymphovascular space invasion (LVSI), and histological type).





This retrospective, comparative study included 40 patients with CC who underwent complete clinical staging and 80 healthy controls at a tertiary center between 2007 and 2017. Groups were compared using independent sample t-tests and Mann–Whitney U tests. Variables with a p<0.05 were included in the receiver operating characteristic curve analysis to determine cut-off values. The associations of PIs with pathological features were analyzed using the chi-square test.



The mean age of patients with CC was 56.9 years old. Demographic characteristics (i.e., age, gravidity, and parity) did not differ between the groups (p>0.05). Mean MPV and PCT were significantly lower (p=0.002 and p=0.026, respectively), and PDW was significantly higher (p=0.049) in the CC group than in the control group. The platelet count did not differ significantly between the groups (p=0.558). The optimal cut-off points of MPV, PDW, and PCT levels for discriminating between the groups were 10.45 fL, 13 fL, and 0.28%, respectively. Except a significant relationship between low PCT level and positive LVSI (p=0.01), there was no significant relationship between PIs and pathological features.



Low MPV and PDW and high PCT may be considered as a useful additional tool for preoperative diagnosis of CC. However, the usability of these markers for predicting pathological features is unsatisfactory.



Cite this article as: Taş EE, Yeğin GF, Keskin HL, Kır EA, Yavuz AF. Is There Any Correlation Between Preoperative Platelet Indices and Surgical Prognostic Factors in Patients with Cervical Cancer?. Cyprus J Med Sci 2019; 4(1): 38-42.

Key Words
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