E-ISSN: 2536-507X ISSN: 2149-7893
Renal Cell Carcinoma: A 10-Year Retrospective Study
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Original Article
VOLUME: 6 ISSUE: 2
P: 107-111
June 2021

Renal Cell Carcinoma: A 10-Year Retrospective Study

Cyprus J Med Sci 2021;6(2):107-111
DOI: 10.5152/cjms.2021.2434
Shokouh Taghipour Zahir 1
Zahra Heidarymeybodi 2
Masood Herman 2
1. Clinical and Surgical Pathology, Shahid Sadoughi University of Medical Sciences, Shahid Sadoughi General Hospital, Yazd, Iran
2. Student Research Committee, Shahid Sadoughi University of Medical Sciences, Shahid Sadoughi General Hospital, Yazd, Iran
No information available.
No information available
Received Date: 11.07.2020
Accepted Date: 19.04.2021
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ABSTRACT

BACKGROUND/AIMS

This study was conducted to investigate survival and its associated factors in patients with clear cell renal cell carcinoma (CCRCC).

MATERIAL and METHODS

This retrospective study recruited patients diagnosed with CCRCC in Shahid Rahnemoon Hospital, Yazd, Iran, followed them up from their presentation until their death or end of the study and examined their demographic information and clinical and tumor characteristics. Continuous variables were expressed as mean6SD, and univariate analyses of survival were conducted using the Kaplan–Meier method and log-rank test and multivariate analyses using the Cox regression model.

RESULTS

The study recruited 206 patients, including 132 males, with CCRCC and a mean age of 57.9 6 13.6 years. During the follow up, 53.9% (n =111) of the patients survived and data regarding the survival status of 24.3% (n = 50) patients were missing. The mean survival duration was obtained as 59.9 6 2.7 months. The independent survival indicators were grade 4 (HR: 2.4, 95% CI: 0.4-5.7, P =.02), older age (HR: 4.14, 95% CI: 1.7-8.4, P = .02), and treatment method includes post-operative chemotherapy (HR: 4.9, 95% CI: 1.7-10.8, P = .004) and postoperative radiochemotherapy (HR: 8.4, 95% CI: 1.9-16.2, P = .03).

CONCLUSION

This study found survival to be negatively correlated with grade 4, older age, and treatment method, i.e. post-operative chemotherapy and post-operative radiochemotherapy.